Factor XIII Deficiency

Factor XIII deficiency is a very rare bleeding disorder, affecting 1 in 5 million men and women in the UK. Factor XIII is also known as Fibrin Stabilising Factor (FSF) and the deficiency can be both inherited and acquired. The deficiency is characterised by the production of defective and unstable blood clots as a response to tissue damage. Throughout life, a Factor XIII deficient individual can experience many superficial bleeds, such as bruises and tissue bleeding, although joint bleeds are generally rare. Only Factor XIII deficiency is associated with a high risk of intracranial haemorrhage. Replacement therapy in Factor XIII deficiency has proved to be generally straightforward, owing to the low levels of Factor XIII required to control bleeding.

For further information, please contact your GP.