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Therapy Areas - Immunoglobulins

Haemolytic Disease of the Newborn (HDN)



Photo: Mother and Baby


The chain of events that can lead to Haemolytic Disease of the Newborn

  • RhD-Negative mother gives birth to an RhD-Positive baby.
  • RhD-Positive blood enters the mother's blood system.
  • The mother's immune system removes the RhD-Positive blood by producing antibodies and retains a 'memory' of RhD-Positive blood.
  • The mother carries a second RhD-Positive child.
  • The mother's antibodies can cross the placenta into the unborn baby and her antibodies damage the baby's RhD-Positive red blood cells.


Please contact your GP or Midwife, for further information about the RhD Factor and what it means to you.

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