coagulation factors

Doctor and patient 2

Factor XI Deficiency

Factor XI deficiency is another inherited bleeding disorder, which affects both males and females, and which is rare except in some ethnic groups. In the general population approximately 1 in 100,000 people are affected, whereas for those of Ashkenazi Jewish heritage the prevalence is roughly 1 in 190. Many people with Factor XI deficiency do not experience bleeding problems, but some do, particularly after surgery or trauma. Affected women may bleed excessively during menstruation and after childbirth. When treatment is needed, the patient's Factor XI level can be raised by transfusion of fresh frozen plasma or Factor XI concentrate.

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